Dynamic interactions among proteins of the bacterial flagellar type III secretion apparatus
نویسندگان
چکیده
منابع مشابه
Functional Activation of the Flagellar Type III Secretion Export Apparatus
Flagella are assembled sequentially from the inside-out with morphogenetic checkpoints that enforce the temporal order of subunit addition. Here we show that flagellar basal bodies fail to proceed to hook assembly at high frequency in the absence of the monotopic protein SwrB of Bacillus subtilis. Genetic suppressor analysis indicates that SwrB activates the flagellar type III secretion export ...
متن کاملWeak Interactions between Salmonella enterica FlhB and Other Flagellar Export Apparatus Proteins Govern Type III Secretion Dynamics
The bacterial flagellum contains its own type III secretion apparatus that coordinates protein export with assembly at the distal end. While many interactions among export apparatus proteins have been reported, few have been examined with respect to the differential affinities and dynamic relationships that must govern the mechanism of export. FlhB, an integral membrane protein, plays critical ...
متن کاملInteraction between FliJ and FlhA , components of the 1 bacterial flagellar type III export apparatus
1 Interaction between FliJ and FlhA, components of the 1 bacterial flagellar type III export apparatus 2 3 Tatsuya Ibuki, Yumiko Uchida, Yusuke Hironaka, Keiichi 4 Namba, Katsumi Imada, and Tohru Minamino 5 6 a Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan 7 b Department of Macromolecular Science, Graduate School of Science, Osaka 8 University, 1-1 Machikaneyama...
متن کاملInteraction between FliJ and FlhA, components of the bacterial flagellar type III export apparatus.
A soluble protein, FliJ, along with a membrane protein, FlhA, plays a role in the energy coupling mechanism for bacterial flagellar protein export. The water-soluble FliH(X)-FliI(6) ATPase ring complex allows FliJ to efficiently interact with FlhA. However, the FlhA binding site of FliJ remains unknown. Here, we carried out genetic analysis of a region formed by well-conserved residues-Gln38, L...
متن کاملFunction of FlhB, a Membrane Protein Implicated in the Bacterial Flagellar Type III Secretion System
The membrane protein FlhB is a highly conserved component of the flagellar secretion system, and it plays an active role in the regulation of protein export. In this study conserved properties of FlhB that are important for its function were investigated. Replacing the flhB gene (or part of the gene) in Salmonella typhimurium with the flhB gene of the distantly related bacterium Aquifex aeolicu...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.664.2